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Distribution kinetics and intestinal absorption of practolol in the rat
Author(s) -
BARBER H. E.,
BOURNE G. R.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb08049.x
Subject(s) - practolol , compartment (ship) , absorption (acoustics) , volume of distribution , chemistry , elimination rate constant , pharmacokinetics , kinetics , distribution (mathematics) , distribution volume , half life , chromatography , pharmacology , endocrinology , biology , mathematics , materials science , mathematical analysis , oceanography , physics , quantum mechanics , composite material , propranolol , geology
Summary1 After intravenous injection of practolol the blood concentration‐time curve is fitted by a bi‐exponential function. A two compartment open system model is therefore a minimal requirement in order to describe adequately the distribution of the drug in the body. 2 The parameters of the two compartment model for practolol were determined. The mean values for the ‘fast disposition’ half life and the ‘slow disposition’ half life were 0.5 min and 13.3 min, respectively. 3 The rate constants of distribution and elimination were similar in different animals. The volume of the central compartment was related to the weight of the animal. 4 The absorption of practolol from an intestinal site was measured by its appearance in the blood. The rate constant for this process was estimated to be 0.03 min −1 .