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Effects of adrenaline on nerve terminals in the superior cervical ganglion of the rabbit
Author(s) -
CHRIST D. D.,
NISHI S.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb08033.x
Subject(s) - excitatory postsynaptic potential , superior cervical ganglion , postsynaptic potential , chemistry , calcium , endocrinology , cervical ganglia , stimulus (psychology) , ganglion , medicine , anesthesia , anatomy , inhibitory postsynaptic potential , receptor , psychology , psychotherapist
Summary1 Adrenaline decreases the release of transmitter from the presynaptic nerves in the superior cervical ganglion of the rabbit. The presynaptic mechanism of adrenaline action was investigated with micro‐electrode techniques. 2 Adrenaline ( 10 −5 M) did not change the threshold of the presynaptic nerve terminals to a current stimulus. 3 The effect of adrenaline on the excitatory postsynaptic potential (e.p.s.p.) was decreased when the calcium concentration of the perfusing solution was increased to 10 m m . 4 The effect of adrenaline on a train of e.p.s.ps (30–50 Hz) was analysed. Adrenaline decreased the readily available stores of transmitter, but only slightly changed the probability of release. 5 The probability of release was increased when the calcium concentration was increased to 5 m m . 6 It was concluded that adrenaline acts directly on excitation release coupling in the presynaptic terminals.