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Central components of the renin‐angiotensin system
Author(s) -
HAYDEN J.,
TARGETT MARGARET A.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb08020.x
Subject(s) - ganglionectomy , hexamethonium , renin–angiotensin system , baroreceptor , medicine , cats , pressor response , angiotensin ii , sympathetic nervous system , kidney , endocrinology , anesthesia , blood pressure , stimulation , heart rate , alternative medicine , pathology
Summary1 Re‐establishment of renal blood flow after total renal ischaemia of 4 h duration causes a pressor response in pentobarbitone anaesthetized rats and cats. 2 The pressor response is related to the release of renin from the ischaemic kidney. 3 Spinal section at any cervical level or stellate ganglionectomy abolishes the pressor response but spinal section caudad to the thorax or vagotomy and treatment with hexamethonium have no effect. 4 Spinal section and stellate ganglionectomy interfere with the release of renin and with the pressor response to angiotensin.