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Determination of the renal clearance of inulin in rats: lowered values at low urine flow rates
Author(s) -
Barber H. E.,
Bourne G. R.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07226.x
Subject(s) - inulin , urine , renal function , urine flow rate , pah clearance , renal blood flow , effective renal plasma flow , extraction ratio , kidney , urine output , urine collection device , urology , chemistry , endocrinology , medicine , chromatography , biochemistry , extraction (chemistry)
The renal clearance of inulin (ClIN) was measured in anaesthetized male rats using a continuous intravenous infusion method.ClIN was independent of urine flow rate provided this was greater than 0.03 ml/minute.At flow rates lower than this, CIIN was reduced and appeared to correlate with the rate of flow.In experiments where a constant kidney function is required. e.g., pharmacokinetic studies, it is advisable to maintain urine, flow rates in the rat above 0.03 ml/minute.