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Effect of p ‐nitromethylamphetamine on biogenic amines and their amino‐acid precursors in rat brain
Author(s) -
LEONARD B. E.,
SHALLICE SUSAN A.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07208.x
Subject(s) - reserpine , tyramine , dopamine , medicine , endocrinology , serotonin , chemistry , tyrosine , tryptophan , biogenic amine , amino acid , norepinephrine , neurotransmitter , pharmacology , central nervous system , biology , biochemistry , receptor
Summary1 Low doses of p ‐nitromethylamphetamine caused small increases in the concentrations of brain noradrenaline and dopamine in the rat; a dose of 60 mg/kg however, caused a decrease in the concentrations of both amines. p ‐Nitromethylamphetamine caused behavioural hyperexcitability only at doses which approximated to half the ld 50 (68 mg/kg). 2 p ‐Nitromethylamphetamine potentiated the action of 4,α‐dimethyl‐ m ‐tyramine in depleting brain noradrenaline. This suggests that it may affect brain noradrenaline concentrations by utilizing a reserpine resistant uptake mechanism. 3 p ‐Nitromethylamphetamine decreased the concentration of brain 5‐hydroxytryptamine. 4 Changes in the blood and brain concentrations of tyrosine and γ‐amino‐n‐butyric acid concentration in the brain could not be correlated with the changes in brain amines. However, a rise in the concentration of brain tryptophan appeared to be correlated with the fall in brain 5‐hydroxytryptamine.