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Effect of receptor blocking drugs on the depletion of brain glycogen by amphetamine
Author(s) -
HUTCHINS D. A.,
ROGERS K. J.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07181.x
Subject(s) - amphetamine , blocking (statistics) , glycogen , pharmacology , chemistry , dextroamphetamine , receptor , neuroscience , endocrinology , medicine , biology , biochemistry , dopamine , computer science , computer network
Summary1 Amphetamine sulphate (5 mg/kg), administered intraperitoneally, reduces the concentration of glycogen in the mouse brain by 25–30% after 30 minutes. 2 The effect of several receptor blocking drugs on the amphetamine‐induced cerebral glycogenolysis was studied. 3 dl ‐Propranolol (0·25 mg/kg) and pronethalol (10 mg/kg) antagonized the depletion of brain glycogen by amphetamine. 4 Phentolamine, methysergide, atropine and mepyramine failed to antagonize the amphetamine‐induced glycogenolysis. 5 d ‐Propranolol, chlorpromazine and phenoxybenzamine antagonized the glycogenolytic effect of amphetamine only when administered in sedative doses. 6 It is concluded that amphetamine‐induced glycogenolysis in the mouse brain may be mediated through a β‐adrenoceptor.