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Evidence for the presence of α‐adrenoceptors in the central thermoregulatory mechanism of rabbits
Author(s) -
DHAWAN B. N.,
DUA P. R.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07180.x
Subject(s) - metaraminol , norepinephrine , medicine , endocrinology , adrenergic receptor , thermoregulation , chemistry , pharmacology , blood pressure , receptor , dopamine
Summary1 The effects of intracerebroventricular administration of some α‐ and β‐adrenoceptor stimulants and antagonists on the body temperature of rabbits were investigated. 2 Noradrenaline produced a dose dependent rise in body temperature. Other catecholamines were less active. 3 The noradrenaline response was blocked by α‐adrenoceptor blocking agents while β‐adrenoceptor antagonists had no effect. 4 α‐Methyl‐noradrenaline and metaraminol had some hyperthermic effect, but significantly reduced the response of noradrenaline. 5 The possible presence of α‐adrenoceptors in the central thermoregulatory mechanisms is suggested.