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Effect of 6‐hydroxydopamine on electrical self stimulation of the brain
Author(s) -
BREESE G. R.,
HOWARD J. L.,
LEAHY J. P.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07177.x
Subject(s) - hydroxydopamine , stimulation , neuroscience , electric stimulation , electrical brain stimulation , medicine , psychology , dopamine , dopaminergic
In rats, after a single intracisternal injection of 6-hydroxydopamine (6-OHDA) electrical self stimulation was reduced by approximately 50%. The concentrations of noradrenaline and dopamine in the brain were reduced by 83%. A second injection of 6-OHDA reduced the concentration of these amines to 7% of control values and virtually eliminated self stimulation.