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Biliary excretion of barbiturates
Author(s) -
KLAASSEN C. D.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07165.x
Subject(s) - probenecid , metabolite , phenobarbital , excretion , chemistry , pharmacology , urine , barbiturate , medicine , pentobarbital , endocrinology , biochemistry
Summary1 Pentobarbitone and phenobarbitone are excreted into the bile of rats. 2 The concentration of pentobarbitone and/or its metabolites in the bile is 22‐fold higher than in the plasma; the concentration of phenobarbitone and/or its metabolites in bile is 10‐fold higher than in the plasma. 3 Probenecid decreases the excretion of the barbiturates into the bile. 4 Twenty‐eight per cent of a 35 mg/kg dose of pentobarbitone and 18% of a 75 mg/kg dose of phenobarbitone is excreted in the bile in 6 hours. 5 Most of the pentobarbitone and phenobarbitone excreted into the bile is not in the form of the parent compound but rather as a more polar metabolite or metabolites.