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Interaction effects of ethanol and pyrazole in laboratory rodents
Author(s) -
BLUM K.,
GELLER I.,
WALLACE J. E.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07157.x
Subject(s) - pyrazole , ethanol , depressant , chemistry , pharmacology , alcohol , biochemistry , stereochemistry , medicine
Summary1 Interactions of pyrazole and ethanol were studied in three laboratory test procedures. They included sleeping time in mice, rotor rod balance in rats and lever pressing behaviour of rats. 2 Equimolar concentrations of pyrazole and 3‐methylpyrazole were compared for effects on enhancement of ethanol's activity on rotor rod holding time of rats. 3 Minimally effective doses of pyrazole, the LADH inhibitor, and 3‐methylpyrazole, a non‐inhibitor of LADH, when administered before ethanol, resulted in an increased behavioural depression. These interaction effects are probably not caused by inhibition of LADH but rather by an increase in the direct depressant action of either one or both of the compounds.