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Role of noradrenaline and 5‐hydroxytryptamine in tetrahydronaphthylamine‐induced temperature changes in the rat
Author(s) -
BRUINVELS J.,
KEMPER G. C. M.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07151.x
Subject(s) - hypothermia , hyperthermia , serotonin , endocrinology , medicine , hypothalamus , preoptic area , chemistry , intraperitoneal injection , thermoregulation , receptor
Summary1 Intraperitoneal administration of graded doses of tetrahydronaphthylamine (THN) to rats caused a dose dependent decrease in body temperature. 2 Intracisternal injection of graded doses of THN induced hypothermia, and implantation of crystalline THN rostral to the medial preoptic area and caudal to the striatum, caused hyperthermia. 3 Pretreatment of the rats with a MAO inhibitor changed the hypothermia into hyperthermia. 4 Intraperitoneal injection of 5‐hydroxytryptophan caused a hypothermia which could be reversed into hyperthermia when the rats were pretreated with a MAO inhibitor. 5 Pretreatment with parachlorophenylalanine enhanced the THN‐induced hypothermia. 6 Depletion of brain monoamines by Ro‐4–1284 in combination with an inhibition of the biosynthesis of noradrenaline (diethyldithiocarbamate) changed the THN‐induced hypothermia into hyperthermia. 7 It is concluded that THN affects body temperature in rats by two central mechanisms, viz. a decrease mediated by noradrenaline, probably in the hypothalamus, and an increase which might be mediated by 5‐hydroxytryptamine rostral to the medial preoptic area.