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Effects of α‐methyl‐ p ‐tyrosine, p ‐chlorophenylalanine, l ‐β‐(3,4‐dihydroxyphenyl)alanine, 5‐hydroxytryptophan and diethyldithiocarbamate on the analgesic activity of morphine and methylamphetamine in the mouse
Author(s) -
MAJOR C. T.,
PLEUVRY BARBARA J.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07137.x
Subject(s) - morphine , analgesic , dopamine , pharmacology , serotonin , tyrosine , chemistry , medicine , anesthesia , biochemistry , receptor
Summary1 The analgesic activity of sympathomimetic drugs does not appear to involve a peripheral component. 2 Drugs causing changes in morphine analgesia have similar effects on the analgesia produced by methylamphetamine. 3 The analgesia produced by morphine and methylamphetamine is increased by drugs which increase the ratio of brain 5‐hydroxytryptamine (5‐HT) to dopamine. 4 The analgesia is decreased by drugs causing a fall in brain 5‐HT or a rise in dopamine relative to 5‐HT.