Premium
Importance of the sympathetic nervous system in the development of renal hypertension in the rat
Author(s) -
GREWAL R. S.,
KAUL C. L.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07135.x
Subject(s) - weanling , endocrinology , medicine , sympathetic nervous system , adrenal medulla , sympathectomy , catecholamine , kidney , blood pressure
Summary1 Chemical sympathectomy with 6‐hydroxydopamine (6‐OHDA) prevented the development of renal hypertension in 80% of weanling male rats of the C.F. strain. 2 Adult male rats treated with 6‐OHDA developed hypertension on bilateral clamping of the renal arteries. 3 Demedullation of the adrenal glands followed by 6‐OHDA treatment in adult rats prevented the development of hypertension in 75% of them. 4 Weanling rats treated with 6‐OHDA did not have any measurable catecholamines in their hearts up to 72–78 days after treatment. 5 Unlike the weanling rats, the hearts of adult rats (demedullated or with intact medulla) showed significant refilling (40–50%) of catecholamine stores 60 days after 6‐OHDA treatment. 6 It is concluded that the functional sympathetic nervous system is important in the development of renal hypertension in the rat.