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Release of dopamine from bovine lung by specific antigen and by compound 48/80
Author(s) -
EYRE P.,
DELINE T. R.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07127.x
Subject(s) - dopamine , antigen , pharmacology , lung , chemistry , medicine , immunology , endocrinology
Summary1 Dopamine was shown to be released from the isolated lung of calves sensitized with horse serum by compound 48/80 and by specific antigen. 2 Dopamine contracts the bovine pulmonary artery and pulmonary vein. Phentolamine, the α‐adrenoceptor blocking agent, inhibits this activity of dopamine and also strongly reduces the Schultz‐Dale response of the pulmonary vessels. 3 The results are consistent with the suggestion that dopamine (together with histamine and 5‐hydroxytryptamine) may participate in the pulmonary vasoconstriction associated with anaphylaxis in cattle.