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Further studies on the effect of ageing on β‐adrenoceptor activity of rat aorta
Author(s) -
Fleisch J. H.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07115.x
Subject(s) - isoprenaline , aorta , ageing , thoracic aorta , medicine , endocrinology , stimulation
beta-Adrenoceptor activity of rat thoracic aorta decreased with the increasing age of the animal. The ability of aortas to relax to isoprenaline was completely lost when rats were 3-6 months old, depending on the source and strain of animals. NaNO(2), however, completely relaxed aortic tissue from animals of all ages tested.