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Effect of oxotremorine on the acetylcholine content of whole brain and various brain regions in the pigeon
Author(s) -
Igić R.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07112.x
Subject(s) - oxotremorine , acetylcholine , brain chemistry , neuroscience , chemistry , biology , muscarinic acetylcholine receptor , pharmacology , endocrinology , biochemistry , receptor
Oxotremorine (0.125 mg/kg) produces a significant increase in total acetylcholine content in whole pigeon brain. The contribution of different regions to this increase varies. The largest increase occurs in the nucleus basalis (paleostriatum augmentatum), a region which is highly involved in motor control. The mechanism by which oxotremorine increases the acetylcholine content of brain and the causal relationship between the rise in acetylcholine content and tremor are discussed.