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Effect of diuretics on mouse blood sugar following single dose administration
Author(s) -
FOY J. M.,
FURMAN B. L.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07110.x
Subject(s) - medicine , endocrinology , adrenalectomy , glycosuria , insulin , diuretic , hydrochlorothiazide , furosemide , blood sugar , diabetes mellitus , blood pressure
Summary1 Frusemide, in doses which were maximal or supramaximal in respect of its natriuretic, diuretic and kaliuretic properties, produced a dose dependent, transient hyperglycaemic response in the mouse. 2 Bilateral nephrectomy resulted in a complete abolition of the hyperglycaemic response. 3 The hyperglycaemic response was accompanied by a decrease in liver glycogen and was significantly attenuated by adrenalectomy, adrenal demedullation and pretreatment with dihydroergotamine (DHE). 4 In the nephrectomized mouse frusemide treatment produced a marked reduction in intravenous glucose tolerance and a reduction in the plasma concentration of immunoreactive insulin following glucose administration. The drug had no detectable effect upon insulin sensitivity. 5 Hydrochlorothiazide exerted no detectable effect on mouse blood sugar. 6 Ethacrynic acid hyperglycaemia was obtainable after intraperitoneal or intramuscular injection, but not after intravenous injection. Intravenously administered ethacrynic acid exerted no effect upon intravenous glucose tolerance or insulin sensitivity in the nephrectomized mouse.