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Cardiovascular actions of substituted adenosine analogues
Author(s) -
ANGUS J. A.,
COBBIN L. B.,
EINSTEIN ROSEMARIE,
MAGUIRE M. H.
Publication year - 1971
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1971.tb07067.x
Subject(s) - dilator , adenosine , medicine , contractility , potency , heart rate , cardiology , blood pressure , pharmacology , endocrinology , chemistry , biochemistry , in vitro
Summary1 The effects of adenosine on systemic blood pressure, coronary blood flow and cardiac contractility and rate were studied in anaesthetized open‐thorax dogs. 2 The potency and duration of action of substituted adenosine analogues were compared with that of adenosine. 3 With the exception of 2‐chloroadenosine, in which coronary dilator activity was enhanced, substitution in the 2‐position of the adenosine molecule reduced activity. 4 In all cases 2‐substitution prolonged the duration of the coronary dilator activity of adenosine. 5 N 6 ‐Methylation of adenosine and 2‐chloroadenosine reduced their coronary dilator activities, but had no effect on the duration of the response. 6 Comparison of the coronary dilator potencies and hypotensive activities of 2‐ethylaminoadenosine and 2‐methoxyadenosine indicates that these analogues have some specificity for the coronary bed.