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The effect of acute administration of ( meta trifluoro methyl‐phenyl)‐l‐(benzoyl oxy) ethyl amino‐2‐propane (780 SE) and fenfluramine on human sleep
Author(s) -
Firth H.,
Lewis S. A.,
Ogunremi O. O.,
Oswald I.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb12909.x
Subject(s) - fenfluramine , sleep (system call) , chemistry , dextroamphetamine , benzodiazepine , amphetamine , pharmacology , medicinal chemistry , medicine , endocrinology , anesthesia , stereochemistry , receptor , computer science , serotonin , dopamine , operating system
In contrast to other amphetamine derivatives, fenfluramine (40 mg) and 780 SE (300 mg) had no effect on the rapid eye movement (REM) phase of sleep. Like other amphetamines they disturbed sleep, increasing the number of shifts to stage 1 (drowsiness) and stage W (arousal).