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The effect of reserpine on the pressor responses to angiotensin in the conscious cat
Author(s) -
DAY M. D.,
OWEN D. A. A.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb12904.x
Subject(s) - reserpine , tyramine , tranylcypromine , endocrinology , medicine , angiotensin ii , renin–angiotensin system , catecholamine , chemistry , norepinephrine , tetrabenazine , blood pressure , monoamine oxidase , dopamine , biochemistry , enzyme
Summary1 Blood pressure recordings have been made in conscious cats in an attempt to reveal a possible indirect component to the angiotensin pressor response. 2 Reserpine (50 to 250 μg/kg per day) caused a maximal reduction of about 50% in the pressor response to angiotensin whilst virtually abolishing the responses to tyramine and McN‐A‐343. Responses to noradrenaline were only slightly and transiently reduced. 3 Syrosingopine (0.5 mg/kg) and reserpine (250 μg/kg) reduced the responses to angiotensin, McN‐A‐343 and tyramine to much the same extent, but tetrabenazine only reduced the responses to all these agents in a dose (25 mg/kg) which probably had effects on the catecholamine stores of smooth muscle. 4 The reduction in the responses to angiotensin, tyramine and McN‐A‐343 by reserpine was partly reversed by tranylcypromine. Noradrenaline and (±)‐dopa infusions were ineffective by themselves, but increased the effects of tranylcypromine in restoring the responses to angiotensin, tyramine and McN‐A‐343 after reserpine. 5 Infusion of α‐methyldopa markedly increased the responses to angiotensin, tyramine and McN‐A‐343 after these had been reduced by reserpine. 6 The results suggest that the pressor response to angiotensin in the conscious cat is partly mediated by release of noradrenaline from peripheral neuronal stores.