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The possible role of adenosine in the coronary dilator action of some pyrimidopyrimidines and pteridines
Author(s) -
NOTT M. W.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb12892.x
Subject(s) - dilator , adenosine , dipyridamole , medicine , cardiology , endogeny , pharmacology , endocrinology
Summary1 The abilities of some pyrimidopyrimidines (including dipyridamole) and pteridine derivatives to potentiate heart block produced by adenosine in the guinea‐pig and to produce coronary dilatation in kitten hearts were investigated. 2 The results demonstrated a correlation between adenosine potentiating and coronary dilating activities of the compounds studied, and are therefore compatible with the concept that compounds of the dipyridamole type owe their coronary dilator activity to potentiation of endogenous adenosine.