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Role of noradrenaline in the acute pressor response to angiotensin in conscious cats
Author(s) -
Day M. D.,
Owen D. A. A.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10664.x
Subject(s) - cats , angiotensin ii , medicine , pressor response , endocrinology , renin–angiotensin system , norepinephrine , stimulation , tyramine , blockade , sympathetic nervous system , adrenergic , blood pressure , heart rate , receptor , dopamine
The changes in the pressor responses to angiotensin after treatment with substances known to modify sympathetic function have been compared with the changes in the responses to noradrenaline, tyramine and McN-A-343 using conscious cats. The responses to angiotensin were not reduced by blockade of adrenergic neurones, alpha and beta-adrenoceptors, or of autonomic ganglia. In conscious cats the acute pressor response to angiotensin does not appear to be related directly to stimulation or facilitation of transmission in sympathetic ganglia or to release of catecholamines from tissue stores.