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pP 2 of eserine and neostigmine on acetylcholine responses of isolated ileum
Author(s) -
Edge N. D.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10638.x
Subject(s) - neostigmine , acetylcholine , ileum , histamine , rectus muscle , chemistry , endocrinology , medicine , pharmacology , biochemistry , anatomy , biology
pP s values of 7·9 and 8·0 for eserine and neostigmine show that these compounds are respectively about 200 and 300 times more potent in potentiating acetylcholine (ACh) responses on isolated cavy ileum than was previously found on frog rectus muscle. The increased tone and spontaneity usually produced by eserine and neostigmine were not prevented by morphine (10 to 100 μg/ml), which itself potentiated both ACh and histamine responses.