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Inotropic effects of thyroxine and related compounds on guinea‐pig left atria in vitro
Author(s) -
Baird J. R. C.,
Spilker B. A.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10636.x
Subject(s) - inotrope , diiodotyrosine , medicine , endocrinology , thyronine , triiodothyronine , guinea pig , reserpine , in vitro , chemistry , thyroid , biochemistry
Triiodothyronine, diiodothyronine and di‐iodotyrosine have positive inotropic activity on normal guinea‐pig left atria in vitro. The increases produced by triiodothyronine and diiodothyronine are small but their detection shows that the inotropic responses to these agents can be studied in vitro. Thyroxine, thyronine and monoiodotyrosine are inactive. Reserpine pre‐treatment reduces the inotropic effect of diiodotyrosine but does not reduce those of triiodothyronine and diiodothyronine.