Premium
Positive correlation between initial pupil diameter and amplitude of miotic response to pilocarpine in rabbits and to carbachol in man
Author(s) -
Burns J.,
Horlington M.,
Robson D.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10635.x
Subject(s) - pilocarpine , carbachol , physostigmine , pupil diameter , correlation , linear correlation , medicine , pupil , anesthesia , positive correlation , chemistry , ophthalmology , neuroscience , biology , acetylcholine , mathematics , receptor , epilepsy , statistics , geometry , psychiatry
A linear correlation between amplitude of miotic response and initial pupil diameter has been demonstrated in rabbits using various concentrations of pilocarpine HC1. The same correlation was found when published results in humans using carbachol were examined and it is likely that the correlation also applies to pilocarpine in humans. No such correlation was observed with physostigmine.