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The effects of “autonomic drugs” on villous movement in the small intestine of the pigeon
Author(s) -
HOOPER PATRICIA A.,
SCHNEIDER R.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10624.x
Subject(s) - small intestine , movement (music) , ileum , medicine , anatomy , biology , neuroscience , philosophy , aesthetics
1 . The responses of pigeon duodenal villi to intravenous injection or local application of “autonomic drugs” were studied and compared with those reported in dogs by other workers. 2 . Choline esters, anticholinesterases, noradrenaline, adrenaline and nicotine all stimulated villous movement in the pigeon. Similar responses to these drugs have been reported in the dog. The effects of these drugs on villous activity could be inhibited by pretreatment of the bird with suitable antagonists, although hexamethonium was ineffective in preventing the effects of nicotine. Some of the antagonists also stimulated the villi. 3 . Isoprenaline caused inhibition of villous movements, which could be prevented by pretreatment of the bird with propranolol. It appears that in pigeons the villi have both α‐adrenoceptors, stimulation of which increases villous activity, and β‐adrenoceptors, stimulation of which depresses villous movements.