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The effect of ethyl alcohol and chlorpromazine on the response of the hand blood vessels to cold
Author(s) -
DOWNEY J. A.,
FREWIN D. B.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10621.x
Subject(s) - chlorpromazine , blood flow , constriction , anesthesia , medicine , alcohol , plethysmograph , chemistry , biochemistry
1 . The response of hand blood flow to a measured cold stimulus was determined using venous occlusion plethysmography in normal subjects, before and after orally administered alcohol, and in patients on chlorpromazine therapy. 2 . The average resting hand blood flow of the patients taking chlorpromazine, as well as the constriction of these blood vessels to cold, was the same as in the normal subjects. 3 . Oral alcohol caused a rise in resting hand blood flow in the normal subjects and also modified the response of the hand blood vessels to cooling. 4 . A patient with a completely denervated hand was also studied. Oral alcohol did not increase the blood flow through the part, but it modified the hand vascular response to cold. 5 . These results suggest a diminished reactivity of the hand blood vessels to cold in the presence of alcohol.