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Effects of morphine and pentobarbitone on acetylcholine synthesis by rat cerebral cortex
Author(s) -
SHARKAWI M.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10613.x
Subject(s) - acetylcholine , morphine , cerebral cortex , pentobarbital , neuroscience , pharmacology , anesthesia , medicine , chemistry , psychology
Summary1 . The synthesis of carbon‐14‐labelled acetylcholine ( 14 C‐ACh) from carbon‐14 uniformly labelled glucose (U‐ 14 C‐D‐glucose) under different conditions was studied. 2 . The ability of cerebral cortex slices and minces from morphine‐treated and pentobarbitone‐treated rats incubated in 4 m m K + medium to form 14 C‐ACh was markedly reduced as compared with those from control animals. 3 . The ability of slices from drug‐treated and control animals incubated in 31 m m K + medium to form 14 C‐ACh was similar. 4 . Cerebral cortex homogenates from both groups of animals in either 4 or 31 m m K + medium formed similar amounts of 14 C‐ACh. 5 . These findings add further support to the hypothesis that the concentration of ACh at the site of synthesis governs the rate of formation of the neurotransmitter.