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The effect of oral contraceptive steroids on bile secretion and bilirubin Tm in rats
Author(s) -
HEIKEL T. A. J.,
LATHE G. H.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10600.x
Subject(s) - mestranol , medicine , endocrinology , bilirubin , chlormadinone acetate , chemistry , population , research methodology , family planning , environmental health
Summary1 . The effect of oestrogens and progestogens and their 17α‐ethinyl derivatives on bile flow, maximum rate of bilirubin secretion, serum and liver bilirubin has been studied. 2 . Both 17α‐ethinyl substituted oestrogens and progestogens greatly reduced the basal bile flow. The parent compounds, oestradiol‐17β and 19‐nortestosterone had little or no effect. 3 . A much larger dose of progestogens (40 mg/kg) than oestrogens (5 mg/kg) was needed. 4 . Between 12 and 48 h were required for 17α‐ethinyloestradiol to produce the effect. 5 . Bilirubin maximum secretion rate ( Tm ) was little affected, the only significant reduction being produced by the 3‐methyl ether of 17α‐ethinyloestradiol (mestranol). 6 . Rises in serum conjugated bilirubin following infusion of bilirubin were produced by 17α‐ethinyloestradiol and mestranol but not by the progestogens.