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Effects of amphetamine derivatives on brain dopamine and noradrenaline
Author(s) -
BREESE G. R.,
KOPIN I. J.,
WEISE VIRGINIA K.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10595.x
Subject(s) - amphetamine , dopamine , dextroamphetamine , norepinephrine , neuroscience , pharmacology , medicine , chemistry , biology
Summary1 . Intracisternally administered metaraminol, α‐methyl‐octopamine, α‐methyl‐ m ‐tyramine, and α‐methyl tyramine were found to lower brain noradrenaline without having an effect on brain dopamine. 2 . Amphetamine, mephentermine, and norephedrine had no effect on brain catecholamines after intracisternal injection. 3 . There was no reduction in brain dopamine content after intracisternal injection of α‐methyl‐ m ‐tyramine, yet the resulting brain concentration of α‐methyl‐ m ‐tyramine was several times higher than after intraperitoneal injection of α‐methyl‐ m ‐tyrosine, which decreased brain dopamine. 4 . The decreased synthesis of labelled catecholamines from 14 C‐tyrosine after α‐methyl‐ m ‐tyrosine suggested that this compound inhibits tyrosine hydroxylase in addition to its action of displacing brain amines.