Premium
Carbon tetrachloride metabolism in sheep and in Fasciola hepatica
Author(s) -
FOWLER J. S. L.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10367.x
Subject(s) - carbon tetrachloride , fasciola hepatica , liver fluke , chemistry , metabolism , excretion , tetrachloride , carbon tetrachloride poisoning , biochemistry , urine , pharmacology , biology , organic chemistry , immunology , helminths , tin
1 The excretion of carbon tetrachloride and its metabolites in bile and urine were studied. 2 Liver flukes in vitro metabolized carbon tetrachloride and hexachloroethane by dechlorination. 3 Carbon tetrachloride, liver lipid from rabbits which received carbon tetrachloride and a carbon tetrachloride methyl oleate complex were toxic to liver flukes in vitro , in the presence of sheep bile. 4 A direct fasciocidal action of carbon tetrachloride may contribute to the therapeutic effect of the drug.