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Oxotremorine‐induced hypertension in the anaesthetized rat
Author(s) -
WALKER JOYCE L.,
WEETMAN D. F.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10357.x
Subject(s) - oxotremorine , atropine , tachycardia , medicine , sympathetic nervous system , blood pressure , endocrinology , anesthesia , muscarinic acetylcholine receptor , receptor
1 Oxotremorine exerts an action on peripheral cholinoceptors in the anaesthetized rat. After the blockade of peripheral cholinoceptors with the quaternary atropine derivative, atropine methylbromide, oxotremorine produced a rise in arterial blood pressure and tachycardia. 2 The rise in arterial pressure and tachycardia was absent in rats that had been pithed or had undergone high spinal cord transection. 3 A non‐quaternary atropine derivative antagonized these cardiovascular effects. 4 Drugs which inhibit activity of the sympathetic nervous system antagonized the oxotremorine‐induced hypertension and tachycardia. 5 It is concluded that the rise in arterial pressure and tachycardia seen in the anaesthetized rat treated with a quaternary derivative of atropine is due to an action of oxotremorine on the central nervous system at a supraspinal level, resulting in an increase in activity of the efferent sympathetic nervous system.