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Effects of drugs on tremor and increase in brain acetylcholine produced by oxotremorine in the rat
Author(s) -
COX B.,
POTKONJAK D.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb10345.x
Subject(s) - oxotremorine , phenoxybenzamine , reserpine , acetylcholine , propranolol , chemistry , pharmacology , endocrinology , medicine , muscarinic acetylcholine receptor , biology , biochemistry , receptor
1 In rats the effect of drugs on oxotremorine tremor and oxotremorine‐induced increase in brain acetylcholine has been investigated. 2 Reserpine, (±)‐α‐methylmetatyrosine and diethyldithio‐carbamic acid, drugs which have in common the ability to decrease tissue noradrenaline concentration, inhibited oxotremorine tremor without preventing the oxotremorine‐induced increase in brain acetylcholine. 3 (±)‐ p ‐chlorophenylalanine, a depletor of tissue 5‐hydroxytryptamine, did not inhibit oxotremorine tremor. 4 Phenoxybenzamine and propranolol inhibited oxotremorine tremor, and propranolol was without effect on oxotremorine‐induced increase in brain acetylcholine. 5 The toxicity of oxotremorine was increased by reserpine and phenoxybenzamine. 6 The significance of these findings is discussed with regard to the mode of action of oxotremorine.