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The effect of benzodiazepines and atropine on exploratory behaviour and motor activity of mice
Author(s) -
AHTEE LIISA,
SHILLITO ELIZABETH
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09928.x
Subject(s) - atropine , chlordiazepoxide , motor activity , diazepam , intraperitoneal injection , pharmacology , medicine , anesthesia , psychology
Summary1 Male albino mice were watched in red light on a tunnel board to test exploration and their motor activity was assessed in an open cage, 30 min after intraperitoneal injection of drugs. 2 Atropine and methylatropine 5 or 10 mg/kg did not alter the motor activity of the mice, while chlordiazepoxide 25 or 50 mg/kg and diazepam 10 or 20 mg/kg increased the activity, especially at the lower of the two doses used. 3 All the compounds used except methylatropine adversely affected the exploratory behaviour. 4 When atropine 10 mg/kg was given with the benzodiazepines, the activity of the mice was reduced and exploratory behaviour was further impaired. Methylatropine did not have this effect.