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Facilitation of the flexor reflex in the cat by intrathecal injection of catecholamines
Author(s) -
DHAWAN B. N.,
SHARMA J. N.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09917.x
Subject(s) - strychnine , metaraminol , facilitation , cats , reflex , alpha (finance) , histamine , clonidine , medicine , endocrinology , anesthesia , pharmacology , vasopressin , chemistry , neuroscience , biology , blood pressure , construct validity , nursing , patient satisfaction
Summary1 Effects of some α‐ and β‐adrenoceptor stimulants and antagonists were investigated on flexor reflex (FR) in chloralosed cats. 2 Noradrenaline (NA) produced facilitation of FR which was dose‐dependent and reproducible and was blocked by α‐adrenoceptor blocking agents. 3 Strychnine also produced facilitation of FR but the response was unaffected by α‐adrenoceptor blocking agents. 4 Metaraminol and α‐methyl‐noradrenaline had little effect on FR but blocked the NA response. 5 β‐adrenoceptor stimulants and antagonists had neither any effect on FR nor modified the NA response. 6 Vasopressin and histamine also failed to modify FR. 7 Possibility of α‐adrenoceptors in the neurones integrating FR is suggested.