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The effects of histamine in malaria
Author(s) -
MAEGRAITH B. G.,
ONABANJO A. O.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09902.x
Subject(s) - histamine , malaria , neuroscience , medicine , biology , immunology , pharmacology
Summary1 Extracts of the blood of monkeys ( Macaca mulatta ) infected with Plasmodium knowlesi contain histamine. A mean total concentration of 0·15 μg/ml was present in the circulating blood. 2 No histamine was detected in the blood of healthy monkeys. 3 Vasodilatation and increased vascular permeability was observed at the site of injection of the extract into the skin and brain of guinea‐pigs. 4 Infiltration of the dermal layer by leucocytes was observed after intradermal injection of the histamine extract. A similar response was obtained in the brain. 5 The extract of the blood from the infected animal produced hypotension in rabbits when administered intravenously. 6 The pathophysiological significance of histamine in malaria is discussed.