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An ultrastructural and histochemical study of the short‐term effects of 6‐hydroxydopamine on adrenergic nerves in the domestic fowl
Author(s) -
BENNETT T.,
BURNSTOCK G.,
COBB J. L. S.,
MALMFORS T.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09889.x
Subject(s) - hydroxydopamine , adrenergic , vesicle , degeneration (medical) , ultrastructure , fowl , catecholamine , axoplasmic transport , axoplasm , chemistry , anatomy , biology , endocrinology , pathology , medicine , dopamine , biochemistry , axon , receptor , paleontology , dopaminergic , membrane
Summary1 The effects of 6‐hydroxydopamine (6‐OHDA) on adrenergic nerves in the domestic fowl have been investigated with ultrastructural and fluorescence histochemical methods. 2 6‐OHDA depletes the nerves of catecholamine, initially by displacing it from the storage vesicles. 6‐OHDA enters large as well as small vesicles, indicating that large granular vesicles in adrenergic nerves are sites of amine storage. 3 Doses of 6‐OHDA, insufficient to cause degeneration, still cause loading of the vesicles. 4 The effects of various drugs on the action of 6‐OHDA indicate that this drug must be taken up by the nerves and reach a critical extragranular axoplasmic concentration before degeneration will occur; 6‐OHDA bound in the vesicles plays no part in the degenerative process.