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Mechanism of the antagonism of the hypotensive action of guanethidine by propranolol
Author(s) -
GREWAL R. S.,
KAUL C. L.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09886.x
Subject(s) - guanethidine , propranolol , physostigmine , endocrinology , medicine , norepinephrine , stimulation , cats , pharmacology , cholinergic , dopamine
Summary1 Propranolol antagonizes the hypotensive effect of guanethidine in renal hypertensive but not in adrenal demedullated renal hypertensive rats. 2 Guanethidine does not interfere with the release of catecholamines from the adrenal gland which follows splanchnic nerve stimulation in cats anaesthetized with pentobarbitone. 3 Guanethidine does not release or interfere with the release of catecholamines after the intravenous injection of physostigmine in the rat. 4 Propranolol antagonizes the antihypertensive effect of guanethidine by potentiating the vasopressor effects of catecholamines released from the adrenal glands during the induction stage of ether anaesthesia.