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Effect of organic nitrates on myocardial oxygen consumption in vitro
Author(s) -
LEVY J. V.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09883.x
Subject(s) - isosorbide dinitrate , oxygen , chemistry , nitration , oxidative phosphorylation , mannitol , isosorbide , biochemistry , medicine , organic chemistry
Summary1 Mannitol hexanitrate (MANHN), iditol hexanitrate and sorbitan tetranitrate, all at 442 μ m , stimulate oxygen uptake by isolated rabbit atrial tissue. 2 At the same concentration, glyceryl trinitrate decreased oxygen uptake, while isosorbide dinitrate and erythrityl tetranitrate had no effect. 3 No simple correlation was found between the lipoid solubility or per cent nitration of these compounds and their effects on oxygen uptake. 4 The stimulating effect of MANHN and its possible role as an uncoupler of oxidative phosphorylation is discussed.