Premium
The spontaneous release of prostaglandins into the cerebral ventricles of the dog and the effect of external factors on this release
Author(s) -
HOLMES S. W.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09874.x
Subject(s) - cerebral ventricle , tranylcypromine , prostaglandin , medicine , endocrinology , stimulation , cerebrospinal fluid , chemistry , ventricle , serotonin , anesthesia , biochemistry , monoamine oxidase , enzyme , receptor
Summary1 Prostaglandins E 19 E 2 , F 1α and F 2α have been identified in perfusates of the cerebral ventricles of anaesthetized dogs. 2 Infusions of serotonin into the lateral ventricle caused a four‐fold increase in the release of prostaglandins E into the ventricles and this increase was dissociated from the hyperthermic action. Intraventricular infusions of adrenaline and noradrenaline had no effect on the level of prostaglandin release. 3 Neither electrical stimulation of a hind foot pad nor the intraperitoneal administration of chlorpromazine, amphetamine, tranylcypromine or imipramine had any consistent effect on the amounts of prostaglandins released into the cerebrospinal fluid. 4 When prostaglandin E 1 was added to the fluid perfusing the ventricular system, respiratory changes were observed but almost all the added prostaglandin was recovered from the perfusate leaving the cisterna.