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Dissociation of potentiation of isoprenaline by cocaine from inhibition of uptake in cat spleen
Author(s) -
DAVIDSON W. J.,
INNES I. R.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09567.x
Subject(s) - isoprenaline , reserpine , cats , long term potentiation , spleen , chemistry , endocrinology , medicine , pharmacology , stimulation , receptor
Summary1 . Cocaine hydrochloride, 10 μg/ml, potentiated isoprenaline and noradrenaline in isolated spleen strips from normal cats and from cats treated with reserpine 24 h previously. 2 . Isoprenaline was taken up almost as well as noradrenaline by spleen strips from cats treated with reserpine. 3 . Cocaine blocked uptake of noradrenaline but did not reduce uptake of isoprenaline. Drug concentrations used in these studies were the same as in potentiation experiments. 4 . It is concluded that inhibition of uptake is not the mechanism by which cocaine potentiates the effect of isoprenaline on the spleen and might be only a contributory factor in the case of noradrenaline potentiation.