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1‐Isopropylamino‐3‐(4‐indanoxy)‐2‐propanol HCl: a potent β‐adrenoceptor antagonist
Author(s) -
LEVY B.,
WASSERMAN M.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09563.x
Subject(s) - propranolol , chronotropic , antagonist , isoprenaline , endocrinology , inotrope , medicine , chemistry , practolol , guinea pig , pharmacology , heart rate , receptor , stimulation , blood pressure
Summary1 . The β‐adrenoceptor blocking activity of 1‐Isopropylamino‐3‐(4‐indanoxy)‐2‐propanol HC1 (USVC 6524) was determined in the anaesthetized dog, the isolated rat uterus and the isolated guinea‐pig tracheal strip. 2 . USVC 6524 inhibited the positive inotropic, positive chronotropic and vasodilator responses to isoprenaline in the dog in a dose of 10 μg/kg and higher. On the basis of comparative pA 2 values, USVC 6524 is approximately 10 times more potent as a β‐adrenoceptor antagonist than propranolol. 3 . Cardiac depressant effects produced by USVC 6524 were relatively mild and occurred only after the onset of a strong β‐adrenoceptor blockade. 4 . USVC 6524 also blocked β‐adrenoceptors in the isolated rat uterus and guinea‐pig tracheal spiral strip.