Premium
The effect of reserpine treatment and decentralization on the ion distribution in the vas deferens of the guinea‐pig
Author(s) -
WESTFALL D. P.,
Burn J. H.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09561.x
Subject(s) - vas deferens , reserpine , guinea pig , chemistry , stimulation , distribution (mathematics) , endocrinology , medicine , pharmacology , biology , mathematical analysis , mathematics
Summary1 . The ion distribution in the vas deferens of the guinea‐pig was determined following reserpine treatment and decentralization, procedures known to increase the sensitivity of this muscle to drug stimulation. 2 . There were no significant changes in the estimated intracellular ion concentrations following the two procedures. The half‐times of 42 K and 36 C1 effluxes were also unaltered. 3 . As far as ion content is concerned there is no basis for suggesting an altered resting membrane potential in supersensitive smooth muscle.