Premium
Some factors influencing the release of 5‐hydroxyindol‐3‐ylacetic acid in the forebrain
Author(s) -
PADJEN A.,
RANDIĆ MIRJANA
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb09550.x
Subject(s) - forebrain , probenecid , stimulation , cerebral cortex , endocrinology , medicine , chemistry , cortex (anatomy) , neuroscience , biology , central nervous system
Summary1 . Electrical stimulation of the mid‐brain raphé in anaesthetized adrenalectomized rats produced a significant decrease in the forebrain content of 5‐hydroxytryptamine (5‐HT) and an increase in the concentration of 5‐hydroxyindol‐3‐ylacetic acid (5‐HIAA). 2 . Stimulation of peripheral sensory nerves did not influence either the forebrain content of 5‐HIAA or the efflux of 5‐HIAA from the cerebral cortex. 3 . Probenecid (200 mg/kg) caused a twofold increase in 5‐HIAA content of the rat's forebrain, while the efflux of 5‐HIAA from the cerebral cortex remained unchanged. 4 . Stimulation of the mid‐brain raphé in animals pretreated with probenecid does not produce the rise in the forebrain levels of 5‐HIAA seen in stimulated untreated controls and does not affect the efflux of 5‐HIAA from the cerebral cortex. 5 . In preliminary experiments, lysergic acid diethylamide (LSD 25) substantially reduced and/or prevented the increase in the release of 5‐HIAA in the forebrain observed in untreated animals with raphé stimulation.