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The pharmacology of ambenoxan (2‐(3′,6′‐dioxaheptyl)‐aminomethyl‐1: 4‐benzodioxane), a centrally acting muscle relaxant
Author(s) -
SHAPERO M.,
SOUTHGATE P. J.
Publication year - 1970
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1970.tb08515.x
Subject(s) - muscle relaxant , pharmacology , strychnine , reflex , medicine , anesthesia , skeletal muscle , muscle contraction , peripheral
Summary1 . The intravenous, subcutaneous and oral toxicity of ambenoxan in mice is reported. 2 . Ambenoxan is a centrally acting skeletal muscle relaxant shown to be effective in mice, rats, rabbits, dogs and monkeys without loss of the righting reflex. 3 . It had no peripheral neuromuscular blocking properties. 4 . Decerebrate rigidity was depressed or abolished in the rabbit. 5 . The effects of strychnine, leptazol, or tremorine were not antagonized. 6 . In common with other depressants of the central nervous system, ambenoxan prolonged the sleeping time of hexobarbitone. 7 . Ambenoxan had no local anaesthetic properties. 8 . In the anaesthetized cat the drug lowered the blood pressure and reduced the pressor response to adrenaline but not to noradrenaline.