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The influence of psychotropic drugs on aldolase, mitochondrial malic dehydrogenase and Mg ++ Na + K + adenosine triphosphatase
Author(s) -
CHOWDHURY A. K.,
ROGERS H.,
SKINNER A.,
SPECTOR R. G.,
WATTS D. C.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb10582.x
Subject(s) - chlorpromazine , aldolase a , trifluoperazine , imipramine , chemistry , malate dehydrogenase , prochlorperazine , enzyme , biochemistry , biology , medicine , endocrinology , calmodulin , alternative medicine , pathology , nausea
1 . The experiment investigated the effects of psychotropic drugs on enzymes in vitro . 2 . Chlorpromazine inhibits mitochondrial malate dehydrogenase in concentrations of 1·4 × 10 −4 m and above. No effect was observed below this concentration. 3 . A sharp inflection in the 1/ V /drug plot was also seen with chlorpromazine (1·4 × 10 −4 m ), trifluoperazine (1 × 10 −5 m ), prochlorperazine (1 × 10 −4 m ), and amylobarbitone (8 × 10 −3 m ) acting on rat brain (Na + ‐K + ‐) Mg ++ ‐ATPase and with chlorpromazine (10 −4 m ) and imipramine (3 × 10 −4 m ) acting on aldolase.