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Some properties of the denervated anterior gracilis muscle of the rat
Author(s) -
TURKANIS S. A.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb10578.x
Subject(s) - depolarization , acetylcholine , contracture , atropine , chemistry , muscle contracture , in vivo , gracilis muscle , medicine , neuroscience , anatomy , biology , surgery , microbiology and biotechnology
1 . Microdrops of acetylcholine (ACh) were topically applied to denervated, mammalian skeletal muscle in vivo , and ACh‐evoked depolarization and contracture were recorded simultaneously. 2 . Contracture tension was directly proportional to the degree of ACh‐elicited depolarization. 3 . Atropine and (+)‐tubocurarine increased the amount of ACh required to produce a given amount of depolarization, but these anticholinergic agents did not alter the relationship between the degree of ACh‐evoked depolarization and contracture tension. 4 . Topically applied catecholamines did not produce either depolarization or contracture, despite the fact that parenterally administered catecholamines elicited both responses.