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Interaction between (±)‐amphetamine and atropine on the rat cardiovascular system
Author(s) -
ALLAN DOROTHY,
BAIRD J. R. C.,
ELLIS KATHLEEN E. J.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb10573.x
Subject(s) - atropine , amphetamine , pharmacology , medicine , sympathomimetics , neuroscience , anesthesia , endocrinology , psychology , dopamine
1 . The effects of atropine on the pithed rat blood pressure after (±)‐amphetamine depend on the pattern of the cardiovascular responses to the latter. 2 . If the pressor response to amphetamine is followed by oscillations of blood pressure and a reduction in pulse pressure or by a fall in blood pressure terminating in circulatory failure, atropine increases blood pressure, but if it is not followed by these patterns, atropine decreases blood pressure. 3 . The fall in blood pressure produced by atropine after amphetamine might be due to weak alpha‐adrenoceptor blockade.