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Comparative study of the effect of three antibiotics on renal function
Author(s) -
CALDWELL A. D. S.,
MARTIN A. J.,
TRIGGER D. J.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb09545.x
Subject(s) - probenecid , renal function , creatinine , colistin , sodium , urea , chemistry , pharmacology , saline , excretion , antibiotics , ampicillin , medicine , endocrinology , biochemistry , organic chemistry
1 . Therapeutic doses of colistin sulphomethate sodium B.P. (Colomycin), pento‐N sulphomethylpolymyxin B sodium (Thiosporin) and ampicillin B.P. (Penbritin) as well as normal saline have been given to volunteers with normal kidney function. 2 . A blind crossover technique was used and the effects of the compounds on blood levels and clearances of urea and creatinine studied. 3 . All four treatments resulted in some changes in the parameters measured but were reversible. The most marked changes were found with pento‐N sulphomethylpolymyxin B sodium and were also associated with severe side‐effects. 4 . In contrast to penicillins it is established that the process of tubular secretion sensitive to probenecid block plays no part in the renal excretion of polymyxins.