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Studies on the mode of action of hexobendine, a prospective anti‐anginal drug
Author(s) -
McINNES LINDA,
PARRATT J. R.
Publication year - 1969
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1969.tb09544.x
Subject(s) - contractility , blood pressure , medicine , cats , heart rate , norepinephrine , cardiac output , blood flow , chemistry , cardiology , anesthesia , dopamine
1 . In cats anaesthetized with pentobarbitone sodium, hexobendine (0.25 mg/kg) markedly increased myocardial blood flow (measured using a heat clearance technique) and usually decreased myocardial metabolic heat production, without influencing cardiac contractility or systemic arterial blood pressure. These effects lasted for about 45 min. 2 . Larger doses (0.5 and 1.0 mg/kg) decreased systemic arterial blood pressure and the rate of rise of the left ventricular pressure pulse (d p /d t ), although left ventricular end‐diastolic pressure was usually increased. This is indicative of a decrease in myocardial contractility. 3 . In a concentration of 5 × 10 −6 g/ml., hexobendine protected isolated rabbit atria against the decrease in contractility that follows the removal of oxygen. 4 . Hexobendine did not antagonize the systemic and myocardial effects of infusions of adrenaline and noradrenaline, nor (except in concentrations of 10 −5 g/ml.) the increase in contractility induced by these catecholamines on isolated rabbit atria.